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Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

Nuclear factor-kappa B (NF-B) and activator protein-1 (AP-1) are key transcriptional regulators of the inflammatory response, promoting the upregulation of pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor- (TNF-)