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POLG-related disorders should be suspected in patients with a family history or suggestive symptoms of a POLG-related disorder, including but not limited to unexplained encephalopathy, refractory epilepsy (focal, myoclonic), status epilepticus at presentation, developmental delays, psychomotor regression, axonal sensorimotor neuropathy, myopathy cerebellar ataxia, ophthalmoplegia, or complicated migraine with occipital aura

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What to Expect: More stable energy throughout the day Improved exercise performance and recovery Better stress tolerance Still minimal weight changes Research Context: Studies show NNMT inhibition improves cellular energy expenditure within 2-4 weeks

Not only were many of these treatments controversial, but they also came with significant safety concerns

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