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Cell culture studies showed that GSH deficiency induced in vitro caused increased oxidative stress, downregulation of VDBP/VD-25-hydroxylase/VDR, upregulation of CYP24A1 in hepatocytes, and downregulation of PGC-1/VDR/GLUT-4 in myotubes [56]

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The no DAC form lacks the Drug Affinity Complex modification, which in other versions allows prolonged binding to albumin and extended activity

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