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Compared with current therapies for RA, which show success in targeting various aspects of inflammatory pathways, the SP-based therapy in this work targeting both the synovial inflammation and RANKL-induced osteoclast differentiation is more promising as an off-the-shelf therapeutic for the alleviation of RA

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difficile risk, and possible increased fracture risk Rebound acid hypersecretion occurs when stopping PPIs abruptly after more than 8 weeks of use

276 (Pt 2), R1541R1544 (1999)