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In terms of association with disease symptoms, they found a correlation between lower abundance of Eubacterium hallii and increased severity of motor signs in HDGEC, and higher probability of developing symptoms in the next 5 years in premanifest participants

All the three transactivation domains are able to recruit co-activators and histone acetyltransferases including CREB binding protein (CBP) and Brahma-related gene1 (BRG1) to promote gene expression [14]

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