Another unusual feature of CXCL17 is that it is active only at high concentrations, with optimal activity at concentrations up to 1000-fold higher than those typically observed for most chemokines (M vs
doi:10.1152/ajpendo.00201.2006 Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ
Conclusion: After a comprehensive evaluation of molecular structure, clinical data, IGF-1 signaling, fat-loss efficacy, side-effect profiles, and long-term research utility, the answer is nuanced but clear
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