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All mice were housed (5 per cage) in clear, pathogen-free polycarbonate cages in the animal care facility and were fed with a standard animal diet and water ad libitum under controlled temperature conditions with 12 h light-dark cycles

Our findings underscore the critical role of the ECM in orchestrating MC function and differentiation, highlighting the need for further studies to fully understand the intricate crosstalk between mechanical parameters and ECM ligands in the cellular microenvironment (Fig

These integrated metabolic-signaling-anti-inflammatory networks provide novel therapeutic targets for intervention

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