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Non-immunogenic , meaning they are unlikely to trigger allergic or inflammatory reactions

These include: Hemodialysis Hemodialysis also often involves blood transfusion and/or administration of erythropoietin or its analogs either of which also require a TUE Treatment for Sickle Cell Disease involves homologous blood transfusions which are prohibited If an athlete requires a Prohibited treatment involving the removal and reintroduction of blood into the circulation for any legitimate medical condition, they should apply for a Therapeutic Use Exemption (TUE) before undergoing the treatment

The main risks are skin irritation with high concentrations and the contamination concerns associated with poorly sourced or improperly prepared formulations

Since B12 is processed in the liver, excessive amounts could potentially lead to complications in severe liver conditions

Authors : Ming-Jer Hsieh, Cheng-Hung Lee, Ho-Yen Chueh, Gwo-Jyh Chang, Hsiu-Yun Huang, Yuling Lin & Jong-Hwei S