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doi:10.1152/ajprenal.00729.2010 262

Red flag symptoms that warrant prompt evaluation include: Severe or persistent abdominal pain , particularly sudden severe epigastric pain radiating to the back, which may suggest pancreatitisa rare but serious adverse effect of GLP-1 receptor agonists Persistent nausea and vomiting that prevents adequate oral intake or leads to dehydration Dysphagia (difficulty swallowing) or odynophagia (painful swallowing), which may indicate oesophageal pathology Unintentional weight loss beyond what is expected, or signs of malnutrition Haematemesis (vomiting blood) or melaena (black, tarry stools), which may indicate gastrointestinal bleeding New or worsening symptoms of gastro-oesophageal reflux , such as heartburn or regurgitation Right upper quadrant pain, fever, or jaundice , which may suggest gallbladder disease For urgent concerns, patients should contact NHS 111 for advice

May your needles stay sharp, your injections stay painless, and your tirzepatide stay potent.

Ethics statement The animal study was approved by Oujiang Laboratory Animal Ethics Committee

Intl Med