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Hirudin, a direct thrombin inhibitor, has also demonstrated anti-metastatic properties [145]

It converts lipid hydroperoxides into less harmful lipid alcohols, preventing oxidative damage (91,92)

While expression levels of canonical mitophagy markers such as PINK1 [72, 120], BNIP3 [121, 122], and LC3 [123, 124] in tumor tissues are frequently correlated with clinical outcomes, their utility is limited by conflicting prognostic associations