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Single-dose studies suggest that the effect of alpha-GPC on TMAO levels is modest, at most, although an observational study linked alpha-GPC supplementation with increased risk of stroke, with greatest risk among those taking alpha-GPC for more than 12 months

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Saito T, Asai K, Sato S, Hayashi M, Adachi A, Sasaki Y

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However, few large scale clinical trials have assessed the efficacy of dietary sulfur amino acids in reducing oxidative stress