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For individuals with a body mass index (BMI) of 30 kg/m or above (or 27.5 kg/m for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean backgrounds), NICE recommends considering pharmacological interventions alongside lifestyle changes when dietary and exercise modifications alone have been insufficient

Secondary outcome measure Cognitive assessment tools such as K-MMSE, K-CWST, COWAT, K-TMT-E, and GDS, K-IADL showed no significant differences between ALC- and placebo-treated groups (Tables 2 and 4)

Stehouwer et al, 1999)

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