PEK/PERK Polyclonal Antibody, 50ul Miscellaneous MED8 encodes a protein component
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PEK/PERK Polyclonal Antibody, 50ul Miscellaneous MED8 encodes a protein componentThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in
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