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Vitamin B12 is essential for normal blood formation, cellular metabolism, and neurological function

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In the current study, the ratio of Firmicutes to Bacteroidetes was significantly higher in WD control mice compared to both groups of mice transitioned from WD to LD (Fig

2020;19(6):e13124

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)