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GLP-1 drugs also block glucagon, a hormone that raises blood sugar

FIGURE 2 In addition to IGF-1R, insulin-like growth factor binding proteins (IGFBPs) are also required for IGF-1 bioavailability because they interact with IGF-1 with the same affinity as IGF-1R (Perks, 2023)

Sjlund, K., Sandn, G., Hkanson, R