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I suspect it will be the same for GLP-1s, says Dr

[1] [2] Proper injection technique can reduce local reactions: Rotate injection sites among the abdomen, thigh, and upper arm to prevent localized sensitization Allow the medication to reach room temperature before injection (according to the Instructions for Use) [1] Use proper subcutaneous technique with appropriate needle angle Avoid injecting into areas with skin abnormalities, scars, or previous reaction sites Do not reuse needles or share pens between patients Note that upper arm injections may require administration by another person Patient education forms the cornerstone of safe use

For those wondering about the process, semaglutide is typically administered as a weekly injection under the skin

Patients initiating semaglutide therapy should undergo baseline blood pressure assessment as part of comprehensive cardiovascular risk evaluation

Previous evidence indicated that age-related macular degeneration was less likely among patients with diabetes being treated with a GLP-1 receptor agonist, but data were sparse in nondiabetic individuals