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MAO-B MAO-B (Monoamine Oxidase B) is highly and selectively expressed in astrocytes, and its upregulation in reactive states exhibits greater astrocyte specificity than that of TSPO

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Multiple early-phase clinical programs have evaluated agents modulating these mechanisms, such as CCR2/CCL2 blockade (emapaticap pegol, CCX140-B) (Zhou et al., 2025b), IL-6 neutralization (ziltivekimab), and anti-fibrotic candidates like pirfenidone or ASK1 inhibition (selonsertib) (Petrovic et al., 2025) (Figure 6)