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In studies with rats, DSIP administration altered the circadian pain threshold, increasing it during both light and dark periods

Daily administration of two or more synaptogenic compounds simultaneously might overwhelm cellular synthetic capacity or trigger compensatory downregulation faster than either compound would alone, potentially favoring alternating administration schedules where different compounds are used on different days

Monami M, Candido R, Pintaudi B, Targher G, Mannucci E

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EXCLI J 19:1387 Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA (2018) Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating -synuclein transmission and neuroinflammation