APTO-253 TO-253 PMID: 28165467

PMID: 28165467

KB-R7943 produced more pronounced inhibition of caffeine-induced Ca2+ release elicited by 1 mM compared with 0

7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat

Chemical Name: N-(furan-2-yl(8-hydroxyquinolin-7-yl)methyl)isobutyramide

the same Vmax is reached for 0

APTO-253 TO-253 PMID: 28165467APTO 253 (LOR 253, LT 253) inhibits c Myc expression and selectively induces CDKN1A (p21), promotes G0 G1 cell cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO 253 is also an inducer of KLF4 (Krppel like factor 4). Product information CAS Number: 916151 99 0 Molecular Weight: 367. 38 Formula: C22H14FN5 Chemical Name: 2 (5 fluoro 2 methyl 1H indol 3 yl) 1H imidazo[4,5 f][1,10]phenanthroline Smiles: