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Consistently, the STEP (Semaglutide Treatment Effect in People with Obesity) trial [22] demonstrated that after 68 weeks of semaglutide therapy in individuals who are overweight or obese, the average weight loss achieved was 14.9%, with 86.4% of participants achieving a reduction of at least 5% from baseline, and 69.1% and 50.5% achieving reductions exceeding 10% and 15%, respectively

Starting at 250-300mcg regardless of body weight, then adjusting based on response, often works better than jumping to weight-based higher doses

10.1001/jamanetworkopen.2024.0946 78 HuangL.BetjesM

It is based on the naturally occurring peptide Epithalamin, which is extracted from the pineal gland