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Colchicine serves as the core medication, while biologics (primarily IL-1 inhibitors) are indicated for patients with contraindications or intolerance to conventional therapies

Rather, a growing body of evidence suggests that the systemic and local actions of incretins and metabolic hormones modulate multiple pathways that can promote inflammatory and fibrotic injury

Wise dosing is key for all hormone systems

[DOI] [PubMed] [Google Scholar] Murakami M, Nakatani Y, Tanioka T, Kudo I

Taken together, our data indicates a significant role for glutathione, not only in oxidative protein folding of periplasmic proteins, but also by balancing and maintaining the periplasmic redox homeostasis