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By integrating these findings, this review offers new insights into the role of ferroptosis in joint degeneration and highlights its potential as a therapeutic target in osteoarthritis

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For glycemic control in type 2 diabetes, measurable reductions in hemoglobin A1c typically become apparent within 4-8 weeks, with maximum effects often seen at 12-16 weeks

These signaling axes not only govern chondrocyte proliferation and ECM secretion but also modulate epigenetic regulators, including histone acetyltransferases (e.g., p300/CBP) and microRNAs (e.g., miR-140), which stabilize the chondrocyte phenotype by suppressing catabolic genes (e.g., MMP13) and reinforcing anabolic gene expression

A: Yes, for some people