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Without targeted reforms such as tiered pricing, technology transfer, pooled procurement, or licensing agreements, access in resource-limited settings will remain limited [120]

For the shoulder, where multiple structures may be involved in a single injury pattern, this enhanced sensitivity helps coordinate healing across different tissue types

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sUA also activates renal tubular TGF-1/Smad, NF-B, and Erk signaling pathways, prompting inflammatory cell secretion and subsequent macrophage migration (119121)