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The expressions of SIRT3, beclin-1, and LC-3II are downregulated in HG-treated HK-2 cells, accompanied by the activation of the Notch homolog 1 (Notch-1)/hairy and enhancer of split-1 (Hes-1) pathway

Prog Neuropsychopharmacol Biol Psychiaty 2003;27:741-9

Supporting gut function is particularly important among those with autoimmune thyroid conditions like Hashimotos

Molecules 25, 676

One analysis did report a reduced risk of melanoma, but this was a cancer-specific finding rather than evidence that high-dose B vitamins prevent cancer generally